Portugal play surprise package Morocco in the quarter-finals on Saturday and a visibly frustrated Santos took great pains to explain what happened behind the scenes to put the issue to bed.
Cristiano Ronaldo shows no signs of flagging as he approaches his mid-30s but there are plenty of other worries for a team with an ageing central defence and a number of players struggling for form.
Following is reaction to the 2022 FIFA World Cup draw, which was held at the Doha Exhibition and Convention Center in Qatar on Friday.
Portugal will look to their Euro 2020 opener with Hungary to get a head start
They may be over dependent on Cristiano Ronaldo and struggling to replace old faithfuls, yet under the wily leadership of Fernando Santos, Portugal can still be a threat.
Love him or loathe him, there is no denying that Cristiano Ronaldo has had a profound effect on Portugal's national team since making his debut against Kazakhstan in August 2003.
Liverpool's Champions League winning trio of Mohamed Salah, Virgil van Dijk and Sadio Mane joined regulars Cristiano Ronaldo and Lionel Messi on the shortlist for The Best FIFA Men's player award
Images and summary of all the World Cup 2022 qualifiers played across continents on Tuesday.
Hungary and Portugal reached the Euro 2016 knockout stages after a rip-roaring 3-3 draw in which Cristiano Ronaldo netted twice and became the first player to score at four European Championship finals on Wednesday.