Sergio Aguero netted his 13th hat-trick for Manchester City as the champions made light of the absence of the injured Kevin De Bruyne to thrash Huddersfield Town 6-1 and move joint top of the Premier League.
The 32-year-old, who captained the Dutch to third place at the 2014 World Cup in Brazil, has been overlooked by coach Danny Blind, who is not convinced about his form with Fenerbahce.
Luuk de Jong scored a hat-trick and Memphis Depay netted the winner in the third minute of stoppage time as PSV Eindhoven beat Feyenoord 4-3 in a thrilling clash that put them four points clear on Wednesday.
Three time European champions Inter Milan were stunned 2-0 at home by Israeli side Hapoel Beer-Sheva and Manchester United were floored by a late goal from Feyenoord as the Europa League group stage got underway on Thursday.
The victory puts the pressure back on title rivals Liverpool who are at Cardiff City on Sunday and trail by a point with each side having played 34 games.
Ole Gunnar Solskjaer continued his dream start as Manchester United caretaker manager with a 3-1 Premier League win over Huddersfield on his Old Trafford debut in the dugout on Wednesday.
News of all that's transpired on and off the football field
Barcelona closed in on the La Liga title after beating 10-man Atletico Madrid 2-0 in Saturday's top-of-the-table showdown at the Nou Camp as late strikes by Luis Suarez and Lionel Messi gave the Catalans an 11-point lead at the top of the table.