With a comfortable first-leg advantage, Zinedine Zidane rested much of his first team, making 10 changes from the line-up that struggled to a disappointing draw at Celta Vigo on Sunday to fall 16 points behind league leaders Barcelona.
Cristian Tello hit a hat-trick as Barcelona came from behind to win 4-1 in their King's Cup quarter-final first leg at Levante on Wednesday and Lionel Messi celebrated his 400th appearance for the Catalan side.
La Liga champions Barcelona slumped to a shock 2-1 defeat at struggling Leganes and Real Madrid were resoundingly beaten 3-0 by Sevilla on Wednesday as Spain's two biggest clubs lost on the same day for the first time since January, 2015.
Antoine Griezmann headed two goals for Atletico Madrid in a 3-1 victory over Levante that kept them on the heels of La Liga leaders Real Madrid on Saturday.
Champions Barcelona came through a gruelling La Liga test at a rainswept San Mames on Sunday, beating Athletic Bilbao 1-0 thanks to Ivan Rakitic's first-half header.