Three goals in eight first-half minutes sent the Mexican side on their way to victory, with stunning long-range strikes from Nelson Deossa and Jesus Corona coming either side of German Berterame's cool finish.
Real Madrid hit their stride at the Club World Cup on Tuesday, edging Juventus 1-0 to reach the quarter-finals thanks to a second-half strike from academy graduate Gonzalo Garcia.
Mexican midfielder Jesus Corona scored for the second match in a row as 10-man Porto returned to winning ways and moved to the top of the Portuguese Primeira Liga with a 1-0 home win over Maritimo on Wednesday. Porto now have 63 points from 26 matches, two clear of second-placed Benfica with eight rounds remaining in this season's championship in a two-horse race for the title.
Players who have been ruled out or are doubtful for the 2022 World Cup.
Images from football matches played in Italy and Portugal on Sunday.
Bayern edge closer to Bundesliga title after win at Arminia
Mexico's Jesus Manuel Corona weaved his way past five players before firing home in the 80th minute to give his side a 1-1 draw with Venezuela that secured top spot in Group C of the Copa America on Monday.
Leaders Porto suffered a shock 2-1 defeat at Famalicao as Portugal's Primeira Liga became the latest league to return to action following the coronavirus stoppage on Wednesday.
Mexico and Bolivia were booed off the pitch after playing out a drab goalless draw in their opening match of the Copa America on Friday, leaving hosts Chile top of Group A after the first round of matches.
Real Madrid failed to win their Champions League group for the first time in four years when a late goal by substitute Marco Reus allowed Borussia Dortmund to equalise and clinch a 2-2 draw.
Clint Dempsey of the United States took the tournament's Golden Boot Award
Paris St Germain reached the Champions League semi-finals despite a 1-0 home defeat by holders Bayern Munich as they progressed on away goals
Barcelona will meet Manchester United in the Champions League quarter-finals following the draw on Friday while Manchester City face Tottenham Hotspur in an all-Premier League clash.
Manchester United-bound Memphis Depay scored a stunning free kick as Dutch champions PSV Eindhoven beat Heracles.
AS Roma suffered another European humiliation on Tuesday when they had two players sent off, lost 3-0 at home to Porto and missed out on the Champions League group stage.
Jose Mourinho's job could be on the line when Chelsea host Porto in the Champions League on Wednesday and Alex Ferguson has urged the Londoners not to jettison their manager even if the result goes against them.
Mexico scored twice in the final five minutes to beat Uruguay 3-1 in a pulsating Copa America Group C match in which each side had a man sent off on Sunday.
Tottenham Hotspur reached the semi-finals of the Champions League on away goals after a 4-3 (aggregate 4-4) defeat to Manchester City in a breathtaking quarter-final second leg game on Wednesday.
Mexico were booed off the field by a boisterous crowd after being held to a 0-0 draw at home to Costa Rica in the final round of CONCACAF qualifying for the 2014 World Cup on Tuesday, their third successive goalless draw at the Azteca Stadium.
Images from Champions League matches played across Europe on Tuesday
Mexican striker Matias Vuoso and Chile midfielder Arturo Vidal both scored twice in a game that roared from end to end and never let up in intensity.
Liverpool failed to muster a single shot on target in a Champions League game for the first time since a 1-0 defeat to Benfica in February 2006.
Photos from the 2018 World Cup qualifiers played on Tuesday
Photos from the Champions League matches played across Europe on Tuesday
A summary of Thursday night's UEFA Champions League matches.
An inspired performance from Douglas Costa helped Brazil to a 3-0 win over Peru on Tuesday and lifted them into third place in the South American qualifying group for the 2018 World Cup in Russia.