He made history during their opening group match, as Salzburg hammered Genk 6-2.
Former Manchester United captain Roy Keane regrets having apologised to Alex Ferguson after the falling-out which led to him leaving the club in 2005, leaked extracts from his new autobiography have revealed.
Despite all the hype, however, the match will do well to live up to some of the Manchester derby tussles down the years. Here are five of the most memorable: