Striker Edinson Cavani scored a superb hat-trick to give Napoli a 3-1 home win over defending Serie A champions AC Milan on Sunday.
Liverpool head for a decisive Champions League clash at Olympique Lyon on Wednesday with 10 players injured or doubtful for the game and coach Rafa Benitez facing the biggest crisis in his five-year Anfield reign.
European champions Spain beat Belgium 2-1 while England overcame Belarus 3-1 to maintain their undefeated record in the 2010 World Cup qualifiers.
Diego Forlan's extra-time effort sent Atletico Madrid into the Europa League final on away goals at the expense of Liverpool after a 2-2 aggregate draw on Thursday. Atletico will meet Fulham in the May 12 final in Hamburg where they will bid to win their first major European trophy since the European Cup Winners' Cup in 1962.
Giorgio Chiellini's last minute header gave Juventus a 3-2 win at Cagliari in Serie A.
Roma knocked Real Madrid out of the Champions League and reached the quarter-finals, where they were joined by Chelsea and Schalke 04.
AS Roma thrashed Parma 4-0 at home to cut Inter Milan's lead in the Italian Serie A to six points.
Fiorentina fell behind to a spectacular scissors-kick goal from Pandurii's Eric Pereira before hitting back in the last five minutes to win 2-1 on Thursday and lead a charge of teams into the Europa League knockout stages.
Jonathan Soriano scored an incredible goal from near the halfway line to complete a stunning 3-0 win for Salzburg away to once-mighty Ajax Amsterdam in the Europa League round of 32 on Thursday.
After qualifying for the 2014 World Cup with two games to spare everything looked positive for Italy but doubts are creeping in after two poor displays mean they are set to miss out on a place among the top seeds in Brazil.