Rio Ferdinand of Manchester United is tackled by Ludovic Giuly of AS Roma.
Complete Coverage: UEFA Champions League
The English champions made a shaky start at the Stadio Olimpico and their Dutch goalkeeper Edwin van der Sar was lucky to get away with a risky early clearance.
Roma defender Christian Panucci then headed just over the bar from a corner in the 12th.
United tried to fashion a response but Brazilian midfielder Anderson hoofed their first effort well off target and Ronaldo drilled a long-distance freekick wide.