Wimbledon PHOTOS: Nadal beaten by 19-year-old Kyrgios; Sharapova ousted

Two-time champion Rafael Nadal of Spain was beaten in the fourth round at Wimbledon by 19-year-old Nick Kyrgios of Australia 7-6(5), 5-7, 7-6 (5), 6-3 on Tuesday.

The 144th-ranked Kyrgios, a wild-card entry, hit 37 aces and delivered a between-the-legs winner on one point.

He is the first man to get to the quarter-finals on  Wimbledon debut in 10 years.

He's also the first player ranked outside the top 100 to beat the No. 1 since No. 193 Andrei Olhovskiy defeated Jim Courier at Wimbledon in 1992.

Nadal has appeared in five finals at the All England Club. He lost in the second round in 2012 and the first round in 2013.

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Maria Sharapova joined the list of big-name casualties in the Wimbledon women's singles when she was beaten 7-6(4), 4-6, 6-4 in the last 16 by Germany’s Angelique Kerber.

The below-par Russian fought off six match-points in the final set as she tried to keep alive her hopes of a second Wimbledon title to go with her 2004 triumph, but finally succumbed in a nerve-jangling finale.

Both players had been out of action since Saturday, after bad weather meant their fourth-round clash was postponed on Monday, and it was Kerber who was quicker into her stride, leading throughout the first set.

Sharapova found her range to break back at 4-5 but some poor errors allowed the 26-year-old Kerber to win the last three points of the opening set tie-break.

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The Russian hit back to level the match and seemed to be favourite to book a quarter-final place but Kerber, defending for all her worth to keep the more powerful Sharapova at bay, moved into a 5-2 lead in the decider.

Sharapova saved a match point at 2-5 and Kerber's nerve failed her at 5-3 as she served a double-fault on the way to dropping her serve.

The real drama was saved until the end though as Sharapova saved five more match points and looked poised to complete a remarkable comeback.

Kerber would not be denied though and was celebrating when Sharapova fired a backhand long.

The German will have to recover quickly as she faces Canada's Eugenie Bouchard for a place in the semis on Wednesday.

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Australian Open champion Stanislas Wawrinka set up a mouth-watering quarter-final showdown with fellow-Swiss Roger Federer after edging past 19th seed Feliciano Lopez 7-6(5), 7-6(7), 6-3.

The fifth seed had complained about his punishing schedule before the match but was efficiency itself as he won the pivotal points to snatch the first two sets on tie-breaks on the bowl-like Court Two.

Spanish left-hander Lopez, a regular in the second week of Wimbledon, seemed to lose composure in the third set as Wawrinka moved into his first Wimbledon quarter-final.

The 29-year-old's clash with Davis Cup team mate Federer will be his third match in three days after his progress was clogged by weekend rain that made a mess of the schedule.

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Roger Federer was at his imperious best on Tuesday, rattling past familiar foe Tommy Robredo 6-1, 6-4, 6-4 and into the Wimbledon quarter-finals for the 12th time in his career.

In a Court One masterclass, Federer demonstrated all the finesse and dazzling array of strokes that have earned him 17 Grand Slam titles including seven at Wimbledon.

Claycourt specialist Robredo, who like Federer is 32 and has been on the professional tour since 1998, found better range and movement in the third set but it was not enough.

Federer's serve was simply too potent and his net-play too sharp and accurate.

The Swiss master completed his 11th victory in 12 tour meetings over Robredo in an 94 minutes.

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Sabine Lisicki's love-affair with grass continued to blossom as she reached the quarter-finals for the fourth year running with a 6-3, 3-6, 6-4 win over Kazakhstan's Yaroslava Shvedova.

For 50 weeks of the year, the 24-year-old German seems to get lost in the crowd by producing one nondescript performance after another.

But come Wimbledon fortnight and the 2013 runner-up morphs into a world beater and has now reached at least the quarter-finals in each of her last five appearances, having missed the 2010 tournament through injury.

The 19th seed raised a few alarms within her camp on day eight of the championships when she took a medical time out at 1-1 in the third set.

Lying flat on her stomach on Court Three, her back and shoulder was massaged and brought back to life by the tournament trainer.

Although she received further treatment during the changeovers, she maintained her focus and wrapped up victory on her third match point when Shvedova netted a forehand.

Lisicki celebrated by shrieking and falling to her knees in delight and will next face French Open runner-up Simona Halep for a place in the semi-finals.

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French Open runner-up Simona Halep raced to a 6-3, 6-0 fourth round win over Kazakhstan's Zarina Diyas to become just the second Romanian woman to reach the quarter-finals.

The world number three has enjoyed a year of career-best results at consecutive Grand Slams and wasted little time in continuing that trend at the All England Club with a dominant victory on Court Two in just 57 minutes.

Halep became the first Romanian woman to reach a Grand Slam final in 34 years at Roland Garros last month, where she was beaten in three sets by Maria Sharapova.

Tuesday's victory ensured she followed in the footsteps of compatriot Virginia Ruzici, who lost at the quarter-final stage in 1978 and 1981, in reaching the last eight on the grass courts of southwest London.