Rohan Bopanna and his Romanian partner Florin Mergea were beaten in the quarter-finals of the men's doubles at the US Open on Tuesday.
The Indo-Romanian combine, semi-finalists at Wimbledon this year, lost 6-7 (2), 3-6 to Dominic Inglot of Great Britain and Robert Lindstedt of Sweden.
The sixth seeded Bopanna-Mergea had got the better of ninth seeds Canada's Daniel Nestor and Edouard Roger-Vasselin of France 6-7, 6-4, 6-3 in the third round.
In 2010, Bopanna reached his first ever Grand Slam final at Flushing Meadows - in partnership with Pakistan's Aisam-ul Haq Qureshi, the pair losing in two closely fought tie-breaks to the Bryan brothers.
However, there is hope for the Indian yet.
Bopanna and his Chinese Taipei partner, Yung-Jan Chan, are up against the fourth-seeded pair of Leander Paes and Martina Hingis in the semi-finals of the mixed doubles competition.