Sania Mirza was ousted from the Indian Wells WTA Premier tournament after suffering a straight set defeat against World No 26 Anabel Medina Garrigues, at Indian Wells on Sunday.
Sania, a wild card entrant, lost 2-6, 5-7 to Spain's 24th seed in the second round.
Sania had beaten German qualifier Kristina Barrios in the opening round 4-6, 6-2, 6-4.
Sania's challenge is still alive in the doubles event with Russian partner Elena Vesnina.
The second seeds have reached second round after beating Vera Dushevina and Shahar Peer 7-5, 6-2.
They face Timea Bacsinszky and Alberta Brianti in the second round.
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