Third seeds Leander Paes and Mahesh Bhupathi crashed out of the Rome Masters after being outplayed in the super tie-breaker by Americas Sam Querrey and John Isner in the second round.
The ace Indian pair was beaten 3-6, 6-3, 5-10 by their unseeded opponents in 72 minutes.
Paes-Bhupathi had a bye in the first round.
Querrey and Isner are in good form and defeated Rohan Bopanna and Aisam-ul-haq Qureshi in the Madrid Open.