The Spanish title race was invigorated by Barcelona dropping points but the championships are all but sewn up in England and Germany after contrasting wins for Chelsea and Bayern Munich.
Manchester United humbled Manchester City 4-2 in the continent's big derby of the weekend.
England
Chelsea are seven points clear at the top of the Premier League after a fortunate late 1-0 win at strugglers Queens Park Rangers but the story of the weekend was Manchester United's 4-2 thumping of Manchester City.
Third-placed United moved four points above their badly faltering derby rivals in fourth and a point behind second-placed Arsenal, who recorded an eighth league win in a row with a 1-0 success at lowly Burnley thanks to Aaron Ramsey's strike.
Leicester City boosted their once improbable hopes of avoiding the drop with a late 3-2 win at stuttering West Bromwich Albion.
Spain
Barcelona's lead at the top of La Liga was cut to two points as they squandered a two-goal advantage to draw 2-2 at Sevilla while Real Madrid powered their way to a 3-0 home win over Eibar.
Neymar set up Argentine Lionel Messi for Barca's first goal and the Brazilian then converted a perfect free kick but a determined Sevilla, who are now unbeaten in 32 home games, never gave up.
Cristiano Ronaldo continued his hot streak with the opening goal as second-placed Real won while Antoine Griezmann came to the rescue of Atletico Madrid, who are third, with his second of the game after 78 minutes earning the champions a 2-2 draw at Malaga.
Germany
Bayern Munich edged closer to a third successive Bundesliga title after the top four all won, leaving the Bavarians 10 points clear with six matches to play.
Bayern beat Eintracht Frankfurt 3-0 with two goals from Robert Lewandowski and one from Thomas Mueller.
Bayern have 70 points from 28 games, with VfL Wolfsburg on 60, Borussia Moenchengladbach on 53 after beating Borussia Dortmund 3-1 and Bayer Leverkusen on 51. There is then a 10-point gap to fifth-placed Schalke 04.
Italy
Runaway leaders Juventus saw their lead cut to 12 points after they suffered a shock 1-0 defeat at bottom club Parma.
Argentine teenager Jose Mauri scored the only goal for Parma, declared bankrupt in March.
Juventus stayed on 70 points while Lazio moved into second place, going above AS Roma, after they thumped Empoli 4-0 for their eighth consecutive Serie A win.
France
Monaco moved up to third in the Ligue 1 standings after a goal by Anthony Martial and Bernardo Silva's double earned them a 3-0 win at Caen.
Monaco, who travel to Juventus for a Champions League quarter-final first leg on Tuesday, have 58 points from 32 games and lead fourth-placed Olympique de Marseille by one point. OM lost 1-0 at Girondins de Bordeaux.
Paris St Germain, who beat Bastia 4-0 in the League Cup final on Saturday, top the table with 62 points and have a game in hand.
