Neem-based contraceptive developed

The Defence Institute of Physiology and Allied Sciences, New Delhi, claims to have developed a neem-based contraceptive cream called Concept, and may soon begin commercial production.

Researchers say the vaginal contraceptive cream, developed using NIM-76, an extract from oil extracted from neem pods, is safe, with no side effects commonly associated with usage of synthetic spermicides available in the market.

The cream has shown promising results in regulating human fertility during clinical trials on human beings, the researchers claimed.

DIPAS signed a memorandum of understanding at New Delhi on Wednesday with the Hyderabad-based Siris Pharmaceuticals for commercial production after intensive clinical trials, said Arun K Tiwari, programme manager, Society For Biomedical Technology, who is coordinating the project. The Tamil Nadu drug controller had already given them a licence to manufacture it as an ayurvedic product, Tiwari said.

The product allegedly acts on the surface membrane of sperm, causing it to elongate and rupture.

Unlike synthetic spermicides, NIM-76 allegedly has positive side effects, including bactericidal and fungicidal properties. It also does not affect the skin or get absorbed by the body, DIPAS sources said.

DIPAS is now planning an oral contraceptive from neem oil. Called Bitter, it was found to cause prevent implantation of the ovum or cause abortion, depending when it was administered. An extract of Bitter, DNM-5, has also been found to have anti-implantation properties. DIPAS has filed patent applications for the extraction methods in India and abroad. Siris Pharmaceuticals too is planning intensive clinical trials of NIM-76 along with the Hyderabad-based Care Foundation.