The company would be shutting down its Winston-Salem desktop computer manufacturing plant by January 2010.
"Approximately 905 employees will be affected by the closure, with about 600 to be released next month," Dell said in a statement on Wednesday.
The plant closure, being done as part of the firm's efforts to simplify operations and improving efficiency, is expected to be complete by January 2010.
The affected employees would receive severance packages, including severance pay, incentive payments, benefits continuation and outplacement services.
Dell employs more than 78,000 people. "This is a difficult decision, especially for our North Carolina colleagues, but a necessary one for Dell customers and our company.
"The efforts of our team members there have been significant and we're committed to helping them through their transition," Frank Miller, vice president, public business unit supply chain at Dell, said.
In January this year, the company announced the migration of its Ireland-based manufacturing operation to its Poland plant, Later in June, Dell sold its Tennessee re-manufacturing operation.