The 30-share Sensex ended down 130 points at 18,675 and the 50-share Nifty slipped 32 points to close at 5,676.
Asian markets ended mixed with Japan's Nikkei ending at a new 2-month low on Friday weighed down by selling pressure in SoftBank.
The benchmark index ended down 0.15%. Among other Asian indices, the Shanghai Composite, Hang Seng and Straits Times ended up 0.1-0.6%.
European shares opened lower on Friday on rising debt concerns in the euro zone. The FTSE-100, CAC-40 and DAX were down 0.4% each.
Among the sectoral indices on the BSE, IT slipped over 2.6% followed by Realty and Auto down 0.9% and 0.7%, respectively.
However, Consumer Durables, Healthcare and FMCG indices were among the top gainers up 0.2-0.6% each.
Infosys was the top Sensex loser and ended down 5.4% to Rs 2,396 after the company lowered its revenue guidance for the current fiscal 2013 in dollar terms.
Bharti Airtel ended down 2.6% at Rs 260 after the after the telecom services provider lost almost one million mobile customers in September, according to data released by the Cellular Operators Association of India.
Other Sensex losers include, ICICI Bank which closed 1.2% lower while HDFC ended down 1%.
HDFC Bank led the Sensex gainers and ended up 0.9% at Rs 630 after the private lender's profit after tax for the quarter ended September 30, 2012 increased by 30.1% from a year ago to Rs 1,560
crore driven by stable margin, higher interest income and lower provisions.
Other gainers include, TCS, Hindustan Unilever, Gail India and Cipla.
Among other shares, Deccan Chronicle Holdings ended locked in 5% upper limit of circuit filter at Rs 9.60 on reports that the company has sold its IPL franchise, the Deccan Chargers team to Mumbai-based Kamala Landmarc owned by Jitendra Jain.
TTK Prestige has dipped 10% to end at Rs 3,314 on reporting 10% year-on-year (yoy) drop in net profit at Rs 30.28 crore for the second quarter ended September 2012, due to higher raw material and interest cost. Net sales grew 11% at Rs 336 crore on y-o-y basis.
Shares of sugar companies are trading higher by up to 6% after the Rangarajan Committee release the report on sugar decontrol. Balrampur Chini Mills and Dhampur Sugar were among the top gainers while other sugar shares witnessed profit taking at higher levels.
The broader markets ended flat. The BSE mid-cap and small-cap indices ended with marginal gains.
The overall breadth was negative with 1,517 losers and 1,368 gainers on the BSE.